Open AccessTelomere instability in papillary bladder urothelial carcinomas: Comparison with grading and risk of recurrence
Author(s) -
Giuseppe Mucciardi,
Alessandro Galı̀,
Valeria Barresi,
Massimo Mucciardi,
M. Aguennouz,
Antonino Inferrera,
Carlo Magno
Publication year - 2014
Publication title -
indian journal of urology/indian journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.333
H-Index - 30
eISSN - 1998-3824
pISSN - 0970-1591
DOI - 10.4103/0970-1591.134241
Subject(s) - medicine , telomere , telomerase , grading (engineering) , bladder cancer , telomerase reverse transcriptase , cancer , oncology , pathology , urology , gastroenterology , gene , biology , ecology , biochemistry
Shortening of telomere is associated with cellular senescence and cancer. This study aims to investigate the relationship between tumor grade and recurrence in relation to telomere length (TL), telomerase activity (TA) and telomere-binding proteins expression (TBPs) in patients with non-muscle invasive bladder cancer (NMIBC).