Open AccessPenile tuberculosis following intravesical Bacille Calmette-Guérin immunotherapy
Author(s) -
Ananda S. Chowdhury,
Ranjan Kumar Dey
Publication year - 2013
Publication title -
indian journal of urology/indian journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.333
H-Index - 30
eISSN - 1998-3824
pISSN - 0970-1591
DOI - 10.4103/0970-1591.109989
Subject(s) - medicine , glans penis , penis , tuberculosis , immunotherapy , bladder cancer , penile cancer , bcg vaccine , carcinoma in situ , dermatology , glans , urinary bladder , hypersensitivity reaction , complication , mycobacterium bovis , granuloma , transitional cell carcinoma , urology , carcinoma , surgery , cancer , pathology , mycobacterium tuberculosis
Bacille Calmette-Guérin (BCG) is an effective treatment for patients with superficial bladder cancer and bladder carcinoma in situ (CIS). It may cause side effects usually due to local and systemic inflammatory effects. We report a case of a male patient with non-invasive urothelial carcinoma of urinary bladder (Stage T1) who developed caseating granulomas on his glans penis as a complication of intravesical BCG immunotherapy. Though there are other reported cases of BCG dissemination noted in the literature, penile granuloma is rare. The first reported case was published in 1992 and since then only eleven cases are reported. It appears that both direct infectious processes and hypersensitivity reactions contribute to the clinical manifestations of a systemic BCG infection. Our case possibly represents a local infection of M bovis involving the glans penis.