Open AccessCardiac Hypertrophy is Positively Regulated by MicroRNA-24 in Rats
Author(s) -
Juan Gao,
Min Zhu,
Ruifeng Liu,
Jian-Shu Zhang,
Ming Xu
Publication year - 2018
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.232793
Subject(s) - cardiac function curve , h&e stain , muscle hypertrophy , medicine , heart failure , myocyte , flow cytometry , cardiac cycle , cardiology , downregulation and upregulation , cardiac hypertrophy , cell cycle , myofilament , microrna , endocrinology , biology , immunohistochemistry , biochemistry , immunology , cancer , gene
MicroRNA-24 (miR-24) plays an important role in heart failure by reducing the efficiency of myocardial excitation-contraction coupling. Prolonged cardiac hypertrophy may lead to heart failure, but little is known about the role of miR-24 in cardiac hypertrophy. This study aimed to preliminarily investigate the function of miR-24 and its mechanisms in cardiac hypertrophy.