Open AccessVariant of EOMES Associated with Increasing Risk in Chinese Patients with Relapsing-remitting Multiple Sclerosis
Author(s) -
Sheng Chen,
Juan Zhang,
Qi-Bing Liu,
Jingcong Zhuang,
Lei Wu,
Yongfeng Xu,
Hongfu Li,
ZhiYing Wu,
Bao-Gou Xiao
Publication year - 2018
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.226892
Subject(s) - multiple sclerosis , odds ratio , single nucleotide polymorphism , genotype , genome wide association study , confidence interval , allele , medicine , genetics , biology , exact test , allele frequency , genotype frequency , oncology , gene , immunology
Multiple sclerosis (MS) is a common central nervous system autoimmune disorder. Increasing number of genome-wide association study (GWAS) analyses hint that MS is strongly associated with genetics. Unfortunately, almost all the GWAS analyses were Caucasian population based. Numbers of risk loci might not be replicated in Chinese MS patients. Hence, we performed a MassArray Assay to genotype the previously reported variants located in the transcription regulation genes in order to elucidate their role in the Chinese MS patients.