Open AccessSigma-1 Receptor Stimulation with PRE-084 Ameliorates Myocardial Ischemia-Reperfusion Injury in Rats
Author(s) -
Qijun Gao,
Bo Yang,
Jing Chen,
Shi Shu,
Hua Yang,
Xin Liu
Publication year - 2018
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.226076
Subject(s) - enos , agonist , apoptosis , receptor , reperfusion injury , protein kinase b , nitric oxide , medicine , ischemia , cardiac function curve , endocrinology , blot , myocardial ischemia , stimulation , phosphorylation , nitric oxide synthase , chemistry , biochemistry , gene , heart failure
The sigma receptors are a relatively novel receptor group with respect to knowledge of their effect on health. Although the sigma-1 receptor agonist PRE-084 exhibits a cardioprotective effect in some studies, the benefits in cases of myocardial ischemia/reperfusion (I/R) are not clear. The aim of this study was to explore the mechanism of action and assess the effect of PRE-084 on myocardial I/R injury in rats.