Open AccessEffect of Platelet-derived P-selectin on Neutrophil Recruitment in a Mouse Model of Sepsis-induced Acute Kidney Injury
Author(s) -
Xiuhua Li,
Yongbing Qian,
Xiaoxiao Meng,
Ruilan Wang
Publication year - 2017
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.209889
Subject(s) - sepsis , acute kidney injury , medicine , creatinine , platelet , myeloperoxidase , kidney , p selectin , renal function , platelet activation , gastroenterology , infiltration (hvac) , immunology , pathology , inflammation , physics , thermodynamics
Acute kidney injury (AKI) is a severe disease in critically ill patients. Neutrophil infiltration into kidney was associated with the development of AKI, and P-selectin may be involved in the process of neutrophil recruitment in kidney. This study aimed to explore the potential effect of platelet-derived P-selectin on neutrophil recruitment in a mouse model of sepsis-induced AKI.