Open AccessApoptotic Mechanism of Human Leukemia K562/A02 Cells Induced by Magnetic Ferroferric Oxide Nanoparticles Loaded with Wogonin
Author(s) -
Miaoxin Peng,
Xiaoyue Wang,
Fan Wang,
Lei Wang,
Peipei Xu,
Bing Chen
Publication year - 2016
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.195466
Subject(s) - k562 cells , apoptosis , wogonin , mechanism (biology) , chemistry , leukemia , microbiology and biotechnology , cancer research , nanoparticle , biochemistry , biology , nanotechnology , materials science , medicine , immunology , physics , pathology , scutellaria baicalensis , traditional chinese medicine , alternative medicine , quantum mechanics
Traditional Chinese medicine wogonin plays an important role in the treatment of leukemia. Recently, the application of drug-coated magnetic nanoparticles (MNPs) to increase water solubility of the drug and to enhance its chemotherapeutic efficiency has attracted much attention. Drugs coated with MNPs are becoming a promising way for better leukemia treatment. This study aimed to assess the possible molecular mechanisms of wogonin-coated MNP-Fe3O4 (Wog-MNPs-Fe3O4) as an antileukemia agent.