Open AccessDual-specificity Phosphatase 1 Deficiency Induces Endometrioid Adenocarcinoma Progression via Activation of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Pathway
Author(s) -
Yuan Yang,
Jingyi Zhou,
Lijun Zhao,
Baorong Gao,
Xiaoping Wan,
Jianliu Wang
Publication year - 2016
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.181954
Subject(s) - mapk/erk pathway , kinase , dual specificity phosphatase , protein kinase a , phosphatase , microbiology and biotechnology , chemistry , cancer research , cell growth , signal transduction , biology , phosphorylation , biochemistry
Previously, we reported that dual-specificity phosphatase 1 (DUSP1) was differentially expressed in endometrioid adenocarcinoma (EEA). However, the role of DUSP1 in EEA progression and the relationship between DUSP1 and medroxyprogesterone (MPA) are still unclear.