Open AccessCould Intrathymic Injection of Myelin Basic Protein Suppress Inflammatory Response After Co-culture of T Lymphocytes and BV-2 Microglia Cells?
Author(s) -
Zhan-Qun Cui,
Baolong Liu,
Qiaoli Wu,
Ying Cai,
Wei Fan,
Mingchao Zhang,
Weiliang Ding,
Bo Zhang,
Jian-min Kang,
Hua Yan
Publication year - 2016
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.178955
Subject(s) - microglia , myelin basic protein , immune system , immunology , tumor necrosis factor alpha , cd8 , microbiology and biotechnology , interleukin , antigen , chemistry , biology , inflammation , endocrinology , myelin , cytokine , central nervous system
The interaction between activated microglia and T lymphocytes can yield abundant pro-inflammatory cytokines. Our previous study proved that thymus immune tolerance could alleviate the inflammatory response. This study aimed to investigate whether intrathymic injection of myelin basic protein (MBP) in mice could suppress the inflammatory response after co-culture of T lymphocytes and BV-2 microglia cells.