Open AccessAssociation between Long Interspersed Nuclear Element-1 Methylation and Relative Telomere Length in Wilms Tumor
Author(s) -
Huibo Chang,
Jizhen Zou,
Cai He,
Rui Zhao,
Yuanyuan Li,
Feifei Ma,
Zhuo Liu,
Hui Ye,
Jianxin Wu
Publication year - 2015
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.169071
Subject(s) - methylation , dna methylation , telomere , microbiology and biotechnology , deoxycytidine , biology , carcinogenesis , wilms' tumor , bisulfite sequencing , dna , genetics , gene , cancer , gene expression , gemcitabine
DNA hypomethylation of long interspersed nuclear elements-1 (LINEs-1) occurs during carcinogenesis, whereas information addressing LINE-1 methylation in Wilms tumor (WT) is limited. The main purpose of our study was to quantify LINE-1 methylation levels and evaluate their relationship with relative telomere length (TL) in WT.