Open AccessDynamic Alterations in Microarchitecture, Mineralization and Mechanical Property of Subchondral Bone in Rat Medial Meniscal Tear Model of Osteoarthritis
Author(s) -
Degang Yu,
Shao-bo Nie,
Fengxiang Li,
Chuanlong Wu,
Bo Tian,
Wengang Wang,
Xiaoqing Wang,
Zhenan Zhu
Publication year - 2015
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.168045
Subject(s) - subchondral bone , osteoarthritis , cartilage , trabecular bone , medicine , resorption , anatomy , x ray microtomography , pathology , bone resorption , articular cartilage , osteoporosis , radiology , alternative medicine
The properties of subchondral bone influence the integrity of articular cartilage in the pathogenesis of osteoarthritis (OA). However, the characteristics of subchondral bone alterations remain unresolved. The present study aimed to observe the dynamic alterations in the microarchitecture, mineralization, and mechanical properties of subchondral bone during the progression of OA.