Open AccessProcess of Hypertrophic Scar Formation
Author(s) -
Yang Qiu,
Sisi Yang,
Jianglin Tan,
Gaoxing Luo,
He Wang,
Jun Wu
Publication year - 2015
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.167359
Subject(s) - hypertrophic scar , medicine , hypertrophic scars , basal (medicine) , immunohistochemistry , scar tissue , epidermis (zoology) , western blot , pathology , anatomy , biology , surgery , scars , biochemistry , gene , insulin
Hypertrophic scar is one of the most common complications and often causes the disfigurement or deformity in burn or trauma patients. Therapeutic methods on hypertrophic scar treatment have limitations due to the poor understanding of mechanisms of hypertrophic scar formation. To throw light on the molecular mechanism of hypertrophic scar formation will definitely improve the outcome of the treatment. This study aimed to illustrate the negative role of eukaryotic initiation factor 6 (eIF6) in the process of human hypertrophic scar formation, and provide a possible indicator of hypertrophic scar treatment and a potential target molecule for hypertrophic scar.