Open AccessSalvianolic Acid B Down-regulates Matrix Metalloproteinase-9 Activity and Expression in Tumor Necrosis Factor-α-induced Human Coronary Artery Endothelial Cells
Author(s) -
Le Ma,
Yi Guan,
Zhenhong Du
Publication year - 2015
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.4103/0366-6999.166037
Subject(s) - western blot , tumor necrosis factor alpha , p38 mitogen activated protein kinases , microbiology and biotechnology , kinase , iκbα , mapk/erk pathway , electrophoretic mobility shift assay , protein kinase a , matrix metalloproteinase , signal transduction , chemistry , nf κb , biology , endocrinology , biochemistry , gene expression , gene
Salvianolic acid B (Sal B) is a bioactive water-soluble compound of Salviae miltiorrhizae, a traditional herbal medicine that has been used clinically for the treatment of cardiovascular diseases. This study sought to evaluate the effect of Sal B on matrix metalloproteinase-9 (MMP-9) and on the underlying mechanisms in tumor necrosis factor-α± (TNF-α±)-activated human coronary artery endothelial cells (HCAECs), a cell model of Kawasaki disease.