Open AccessVoriconazole for the treatment of refractory Aspergillus fumigatus keratitis
Author(s) -
Hijab Mehta,
Hitendra Mehta,
Prashant Garg,
Harish Kodial
Publication year - 2008
Publication title -
indian journal of ophthalmology/indian journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 51
eISSN - 1998-3689
pISSN - 0301-4738
DOI - 10.4103/0301-4738.40369
Subject(s) - voriconazole , medicine , aspergillus fumigatus , fungal keratitis , refractory (planetary science) , keratitis , aspergillosis , dermatology , antifungal , immunology , astrobiology , physics
We report a case of Aspergillus fumigatus keratitis in a 53-year-old, well-controlled diabetic female who did not respond to standard antifungal treatment. She was started on topical natamycin eye drops, but the infiltrate continued to progress. Topical amphotericin B and systemic ketoconazole was added, however, there was no response and the infiltrate increased further. She was then switched to topical and systemic voriconazole. Steady resolution of the infiltrate was noted within 2 weeks of therapy.