Open AccessGenetic perspective of retinoblastoma: From present to future
Author(s) -
Jagadeesan Madhavan,
Vikas Khetan,
Ashwin Mallipatna
Publication year - 2016
Publication title -
indian journal of ophthalmology/indian journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 51
eISSN - 1998-3689
pISSN - 0301-4738
DOI - 10.4103/0301-4738.185585
Subject(s) - retinoblastoma , medicine , perspective (graphical) , disease , genetic counseling , mechanism (biology) , bioinformatics , gene , pathology , genetics , epistemology , biology , artificial intelligence , computer science , philosophy
Retinoblastoma (RB) is the most common malignant intraocular tumor in children. In the last decade, basic research has led to a better understanding of events after two hits in RB susceptibility gene (RB1), molecular mechanism of tumor growth, the cell of origin of RB, etc. This would pave way to identify biomarkers and molecular targeted therapy for better treatment option in the future. Furthermore, improvement in molecular techniques has led to enhanced diagnostic methods for early diagnosis, genetic counseling, and prevention of the disease. This review will help to understand the essence of basic research work conducted in recent times and its implication in the management of RB in the future.