Open AccessPharmacokinetics of topically applied sparfloxacin in rabbits
Author(s) -
Milan C. Satia,
Vandana D. Mody,
Rajiv Modi,
P Kabra,
Myuri Khamar
Publication year - 2005
Publication title -
indian journal of ophthalmology/indian journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 51
eISSN - 1998-3689
pISSN - 0301-4738
DOI - 10.4103/0301-4738.16676
Subject(s) - sparfloxacin , aqueous humour , pharmacokinetics , medicine , cmax , minimum inhibitory concentration , pharmacology , cornea , aqueous humor , area under the curve , chromatography , ophthalmology , antibiotics , chemistry , ofloxacin , ciprofloxacin , biochemistry
Fluoroquinolones are antimicrobial agents that have a broad spectrum of activity and are widely used against many of the ocular pathogens, responsible for conjunctivitis, blepharitis, corneal ulcers etc. The aim of our study was to evaluate the ocular pharmacokinetics of sparfloxacin (0.3% w/v) in the aqueous humour of rabbits.