Open AccessDNA methylation analysis of secreted frizzled-related protein 2 gene for the early detection of colorectal cancer in fecal DNA
Author(s) -
Hadi Babaei,
Mohsen Mohammadi,
Roya Salehi
Publication year - 2016
Publication title -
nigerian medical journal/nigerian medical journal
Language(s) - English
Resource type - Journals
eISSN - 2229-774X
pISSN - 0300-1652
DOI - 10.4103/0300-1652.188357
Subject(s) - dna methylation , methylation , colorectal cancer , biology , cpg site , cancer research , bisulfite sequencing , cancer , polymerase chain reaction , gene , dna , microbiology and biotechnology , genetics , gene expression
The early detection of colorectal cancer (CRC) with high sensitivity screening is essential for the reduction of cancer-specific mortality. Abnormally methylated genes that are responsible for the pathogenesis of cancers can be used as biomarkers for the detection of CRC. The methylation status of the secreted frizzled-related protein 2 (SFRP2) gene was evaluated for their use as a marker in the noninvasive detection of CRC.