Open AccessPsychosis Following Carbimazole-induced Acute Alteration of Hyperthyroid Status
Author(s) -
Guru S Gowda,
Mallikarjun Rao Sagi,
Sai Komal,
T S Jaisoorya
Publication year - 2017
Publication title -
indian journal of psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 24
eISSN - 0975-1564
pISSN - 0253-7176
DOI - 10.4103/0253-7176.211753
Subject(s) - carbimazole , euthyroid , psychosis , olanzapine , medicine , goiter , antithyroid agent , endocrinology , thyroid , schizophrenia (object oriented programming) , psychiatry , graves' disease
Abrupt normalization of hyperthyroid state with antithyroid drugs is reported to precipitate psychosis. We report the development of acute psychosis in a 20-year-old woman, following 30 days use of tablet carbimazole 10 mg for hyperthyroidism due to the multinodular goiter. At the time of presentation, she was euthyroid with a resolution of hyperthyroid status both clinically and biochemically. After 20 days treatment with tablet olanzapine 10 mg/day and stoppage of carbimazole, psychotic symptoms remitted completely and she has since remained in a euthyroid state and free from psychotic symptoms. This case highlights the development of psychosis in individuals, following rapid restoration to normal serum thyroid hormone levels in hyperthyroid individuals with carbimazole.