Open AccessDesigning of the mucoadhesive intravaginal spermicidal films
Author(s) -
Shilpa Kawarkhe,
SS Poddar
Publication year - 2010
Publication title -
indian journal of pharmaceutical sciences/indian journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.245
H-Index - 57
eISSN - 1998-3743
pISSN - 0250-474X
DOI - 10.4103/0250-474x.78540
Subject(s) - mucoadhesion , folding endurance , swelling , drug delivery , metronidazole , vaginal delivery , chitosan , materials science , polyvinyl alcohol , biomedical engineering , chemistry , chemical engineering , composite material , bioadhesive , nanotechnology , polymer , organic chemistry , ethyl cellulose , antibiotics , medicine , biochemistry , pregnancy , biology , engineering , genetics
A mucoadhesive drug delivery system for local delivery of metronidazole through vaginal route was formulated. Films were prepared by solvent evaporation method using various compositions of Carbopol, hydroxypropylmethylcellulose, chitosan, Polyox and propylene glycol. The films were evaluated for their weight, thickness, surface pH, folding endurance, mechanical, drug content uniformity, in vitro drug release, swelling, gelling and mucoadhesion property. All the films possess satisfactory film characteristics. Films made of Polyox found to possess acceptable, physicochemical, mechanical, gelling and mucoadhesion property for delivery of metronidazole.