Open AccessSynthesis and antimalarial evaluation of some 4-quinazolinone derivatives based on febrifugine
Author(s) -
Debanjan Sen,
Anirban Banerjee,
Ashoke Kumar Ghosh,
Tapan K. Chatterjee
Publication year - 2010
Publication title -
agricultural policy paper
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 33
ISSN - 0110-5558
DOI - 10.4103/0110-5558.76439
Subject(s) - quinazolinone , artemisinin , plasmodium berghei , chloroquine , chemistry , pharmacology , antimalarial agent , in vivo , combinatorial chemistry , plasmodium falciparum , stereochemistry , malaria , medicine , biology , microbiology and biotechnology , immunology
A series of 2-substituted and 2,3-substituted quinazolin -4(3H)-one derivatives were designed and synthesized based on the structure of febrifugine. The structures of the new compounds were confirmed by spectral analysis. The in vivo biological activity test results indicated that those compounds exhibited antimalarial activities against Plasmodium berghei in mice, at a dose of 5 mg/kg. Compared to Chloroquine and Artemisinin, these compounds have the advantages of shorter synthetic routes and consequently are highly cost effective in nature.