Open AccessAssociation between single nucleotide polymorphism in collagen IX and intervertebral disc disease in the Indian population
Author(s) -
Tushar Rathod,
Ajay Chandanwale,
Shubhangi Gujrathi,
Vinayak W. Patil,
Shital Chavan,
Minit Shah
Publication year - 2012
Publication title -
indian journal of orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 33
eISSN - 1998-3727
pISSN - 0019-5413
DOI - 10.4103/0019-5413.97261
Subject(s) - allele , genetics , medicine , population , gene , polymorphism (computer science) , genotype , genetic association , etiology , pathology , single nucleotide polymorphism , biology , environmental health
Symptomatic intervertebral disc degeneration is being recently reported in younger population, questions the basis of its degenerative etiology. Latest evidences show that genetics play a significant role. Collagen IX, an important constituent of disc, is found to be altered in genetically predisposed individuals. Mutations have been reported in COL9A2 and COL9A3 genes, which encode Collagen IX, in Finnish and various other populations. The purpose of the present study is to test the significance of these genes in the Indian population.