Open AccessN-terminal telopeptides of type I collagen and bone mineral density for early diagnosis of nonunion
Author(s) -
Jianping Lin,
Zhanjun Shi,
Shen Ning-jiang,
Jian Wang,
Zao-Min Li,
Jun Xiao
Publication year - 2016
Publication title -
indian journal of orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 33
eISSN - 1998-3727
pISSN - 0019-5413
DOI - 10.4103/0019-5413.185608
Subject(s) - nonunion , medicine , bone healing , bone mineral , bone resorption , bone remodeling , dentistry , type i collagen , surgery , osteoporosis , urology
The diagnosis and treatment of bone nonunion have been studied extensively. Diagnosis and treatment of nonunion are mainly performed based on the interpretation of clinico-radiographic findings, which depend on the clinician's experience and the degree of bone callus formation during the fracture-healing process. However, resolution may be compromised when the bone mineral content is <25%. A feasible method of monitoring bone-healing is therefore needed. We monitored a rabbit model of bone nonunion by regular radiographic examinations, QCT detection, and biomarker concentrations.