Open AccessEffect of insulin-like growth factor-1 and hyaluronic acid in experimentally produced osteochondral defects in rats
Author(s) -
Celil Alemdar,
İstemi Yücel,
Barış Erbil,
Havva Erdem,
Ramazan Atiç,
Emin Özkul
Publication year - 2016
Publication title -
indian journal of orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 33
eISSN - 1998-3727
pISSN - 0019-5413
DOI - 10.4103/0019-5413.185607
Subject(s) - hyaluronic acid , medicine , condyle , gelatin sponge , cartilage , insulin like growth factor , femur , articular cartilage , matrix (chemical analysis) , growth factor , chondrogenesis , surgery , biomedical engineering , anatomy , pathology , osteoarthritis , chemistry , chromatography , embolization , receptor , alternative medicine
The common purpose of almost all methods used to treat the osteochondral injuries is to produce a normal cartilage matrix. However current methods are not sufficient to provide a normal cartilage matrix. For that reason, researchers have studied to increase the effectiveness of this methods using chondrogenic and chondroprotective molecules in recent experimental studies. Insulin-like growth factor-1 (IGF-1) and hyaluronic acid (HA) are two important agents used in this field. This study compared the effects of IGF-1 and HA in an experimental osteochondral defect in rat femora.