Open AccessThe chondroprotective effects of intraarticular application of statin in osteoarthritis
Author(s) -
Sarp Bayyurt,
Abdullah Küçükalp,
M. Sadık Bilgen,
Ömer Faruk Bilgen,
İlkin Çavuşoğlu,
Ülviye Yalçinkaya
Publication year - 2015
Publication title -
indian journal of orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 33
eISSN - 1998-3727
pISSN - 0019-5413
DOI - 10.4103/0019-5413.168751
Subject(s) - medicine , osteoarthritis , cartilage , anterior cruciate ligament , atorvastatin , chondrocyte , statin , saline , articular cartilage , knee joint , surgery , pathology , anatomy , alternative medicine
Osteoarthritis (OA) is the most frequent chronic joint disease causing pain and disability. Recent reports have shown that statin may have the potential to inhibit osteoarthritis. This study of early stage OA developed in an experimental rabbit model, aimed to evaluate the chondroprotective effects of intraarticularly applied atorvastatin on cartilage tissue macroscopically and histopathologically by examining intracellular and extracellular changes by light and electron microscope.