Open AccessLewy body dementia: Ursodeoxycholic acid as a putative treatment for gastrointestinal dysfunction
Author(s) -
Mohsen Khosravi
Publication year - 2021
Publication title -
european journal of translational myology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.271
H-Index - 6
eISSN - 2037-7460
pISSN - 2037-7452
DOI - 10.4081/ejtm.2021.9876
Subject(s) - ursodeoxycholic acid , lewy body , medicine , autonomic nervous system , dementia , dementia with lewy bodies , gastrointestinal function , enteric nervous system , hepatic dysfunction , pathological , neuroscience , bioinformatics , intensive care medicine , disease , psychology , biology , heart rate , blood pressure
The autonomic nervous system (ANS) is a part of the peripheral nervous system that regulates internal organs function at an involuntary unconscious level. Recent evidence has shown that autonomic dysfunction is a common feature of Lewy body dementia (LBD). A wide range of autonomic symptoms may occur in LBD, which are correlated with poor prognosis. However, there is still no evidence-based approach to developing the best therapeutic strategy for autonomic dysfunction (particularly gastrointestinal symptoms) among LBD patients. This paper was intended to present a new perspective on ursodeoxycholic acid and its potential effects for treating gastrointestinal dysfunction in LBD patients.