Open AccessCardiovascular Regeneration via Stem Cells and Direct Reprogramming: A Review
Author(s) -
Choon-Soo Lee,
Joonoh Kim,
HyunJai Cho,
HyoSoo Kim
Publication year - 2022
Publication title -
korean circulation journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 29
eISSN - 1738-5555
pISSN - 1738-5520
DOI - 10.4070/kcj.2022.0005
Subject(s) - reprogramming , induced pluripotent stem cell , medicine , regenerative medicine , regeneration (biology) , neuroscience , stem cell , heart failure , transplantation , somatic cell , bioinformatics , intensive care medicine , embryonic stem cell , cardiology , microbiology and biotechnology , biology , cell , biochemistry , genetics , gene
Cardiovascular disease (CVD) is the leading causes of morbidity and death globally. In particular, a heart failure remains a major problem that contributes to global mortality. Considerable advancements have been made in conventional pharmacological therapies and coronary intervention surgery for cardiac disorder treatment. However, more than 15% of patients continuously progress to end-stage heart failure and eventually require heart transplantation. Over the past year, numerous numbers of protocols to generate cardiomyocytes (CMCs) from human pluripotent stem cells (hPSCs) have been developed and applied in clinical settings. Number of studies have described the therapeutic effects of hPSCs in animal models and revealed the underlying repair mechanisms of cardiac regeneration. In addition, biomedical engineering technologies have improved the therapeutic potential of hPSC-derived CMCs in vivo. Recently substantial progress has been made in driving the direct differentiation of somatic cells into mature CMCs, wherein an intermediate cellular reprogramming stage can be bypassed. This review provides information on the role of hPSCs in cardiac regeneration and discusses the practical applications of hPSC-derived CMCs; furthermore, it outlines the relevance of directly reprogrammed CMCs in regenerative medicine.