Open AccessCausal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study
Author(s) -
Jung-Ho Yang,
Ji-An Jeong,
Sun-Seog Kweon,
YoungHoon Lee,
Seong-Woo Choi,
So Yeon Ryu,
Hae-Sung Nam,
Kyeong-Soo Park,
Hye Yeon Kim,
Min Ho Shin
Publication year - 2022
Publication title -
korean circulation journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 29
eISSN - 1738-5555
pISSN - 1738-5520
DOI - 10.4070/kcj.2021.0269
Subject(s) - mendelian randomization , aldh2 , medicine , observational study , alcohol consumption , alcohol , aldehyde dehydrogenase , genotype , genetics , gene , genetic variants , biology , biochemistry
Previous observational studies presented a positive association between alcohol and atrial fibrillation (AF). However, previous studies using genetic polymorphisms on the causal relationship between alcohol consumption and AF have reported conflicting results. This study aimed to evaluate the causality between alcohol consumption and AF using the aldehyde dehydrogenase 2 ( ALDH2 ) rs671 polymorphism, which is the genetic variant with the most potent effect on drinking behavior.