Open AccessPolo-Like Kinase 1 Regulates Chromosomal Instability and Paclitaxel Resistance in Breast Cancer Cells
Author(s) -
Mingji Quan,
Yumi Oh,
Sung-Yup Cho,
Ju Hee Kim,
HyeongGon Moon
Publication year - 2022
Publication title -
journal of breast cancer/journal of breast cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 36
eISSN - 2092-9900
pISSN - 1738-6756
DOI - 10.4048/jbc.2022.25.e28
Subject(s) - kinome , cancer research , breast cancer , plk1 , gene silencing , gene knockdown , cancer cell , cancer , medicine , kinase , biology , cell cycle , apoptosis , microbiology and biotechnology , biochemistry , gene
Chromosomal instability (CIN) contributes to intercellular genetic heterogeneity and has been implicated in paclitaxel (PTX) resistance in breast cancer. In this study, we explored polo-like kinase 1 (PLK1) as an important regulator of mitotic integrity and as a useful predictive biomarker for PTX resistance in breast cancer.