Open AccessMutational Analysis of Triple-Negative Breast Cancer Using Targeted Kinome Sequencing
Author(s) -
Tae-Kyung Yoo,
Woo Seung Lee,
Ji Sun Kim,
Min Kyoon Kim,
In-Ae Park,
Grace Juyun Kim,
Wonshik Han
Publication year - 2022
Publication title -
journal of breast cancer/journal of breast cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 36
eISSN - 2092-9900
pISSN - 1738-6756
DOI - 10.4048/jbc.2022.25.e15
Subject(s) - kinome , triple negative breast cancer , medicine , breast cancer , oncology , cancer research , gene , cancer , biology , genetics
Triple-negative breast cancer (TNBC) does not have defined therapeutic targets and is currently treated with chemotherapy only. Kinase dysregulation triggers cancer cell proliferation and metastasis and is a crucial therapeutic target for cancer. In this study, targeted kinome sequencing of TNBC tumors was performed to assess the association between kinome gene alterations and disease outcomes in TNBC.