Open AccessLong Noncoding-RNA Component of Mitochondrial RNA Processing Endoribonuclease Promotes Carcinogenesis in Triple-Negative Breast Cancer Cells via the Competing Endogenous RNA Mechanism
Author(s) -
Liqiang Qi,
Bo Sun,
Baofeng Yang,
Su Lu
Publication year - 2021
Publication title -
journal of breast cancer/journal of breast cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 36
eISSN - 2092-9900
pISSN - 1738-6756
DOI - 10.4048/jbc.2021.24.e42
Subject(s) - triple negative breast cancer , cancer research , gene knockdown , carcinogenesis , competing endogenous rna , cell growth , microrna , rna , biology , long non coding rna , microbiology and biotechnology , apoptosis , cancer , breast cancer , biochemistry , gene , genetics
Triple-negative breast cancer (TNBC) is a subtype of breast cancer. Increasing evidence supports that dysregulation of long noncoding RNAs (lncRNAs) plays a vital role in cancer progression. RNA component of mitochondrial RNA processing endoribonuclease ( RMRP ), a lncRNA, is characterized as a tumor-propeller in some cancers, but its mechanism in TNBC remains poorly understood. This study aimed to determine whether and how RMRP functions in TNBC.