Open AccessClinical Features of Breast Cancer in South Korean Patients with Germline TP53 Gene Mutations
Author(s) -
Hassan Alyami,
Tae Kyung Yoo,
Jong-Ho Cheun,
HanByoel Lee,
SoonMoon Jung,
Jai Min Ryu,
Soong June Bae,
Jeong Eon Lee,
Chung Sik Yoon,
Juneyoung Ahn,
Pill Sun Paik,
Min Kyung Cho,
Woo Chan Park
Publication year - 2021
Publication title -
journal of breast cancer/journal of breast cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 36
eISSN - 2092-9900
pISSN - 1738-6756
DOI - 10.4048/jbc.2021.24.e16
Subject(s) - medicine , breast cancer , germline , germline mutation , gene , oncology , cancer , cancer research , mutation , genetics , biology
Li-Fraumeni syndrome (LFS) is a rare autosomal cancer syndrome caused by a germline mutation in the TP53 gene. Breast cancer in LFS patients is of various subtypes; however, limited data are available on the clinicopathological features of these subtypes and their appropriate treatments. This study aimed to review the clinical features and treatments for breast cancer in South Korean patients with germline TP53 mutations.