Open AccessProtocatechuic Aldehyde Represses Proliferation and Migration of Breast Cancer Cells through Targeting C-terminal Binding Protein 1
Author(s) -
Yu Deng,
Wanjun Guo,
Guancheng Li,
Shuang Li,
Hong Li,
Xinyan Li,
Bei Niu,
Mingxin Song,
Yamei Zhang,
Zhijian Xu,
Fulun Li
Publication year - 2020
Publication title -
journal of breast cancer/journal of breast cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 36
eISSN - 2092-9900
pISSN - 1738-6756
DOI - 10.4048/jbc.2020.23.e7
Subject(s) - cancer research , cancer cell , breast cancer , cancer , microbiology and biotechnology , medicine , biology , genetics
C-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that is overexpressed in many cancers. CtBP1 transcriptionally represses a broad array of tumor suppressors, which promotes cancer cell proliferation, migration, invasion, and resistance to apoptosis. Recent studies have demonstrated that CtBP1 is a potential target for cancer therapy. This study was designed to screen for compounds that potentially target CtBP1.