Open AccessProlactin Inhibits BCL6 Expression in Breast Cancer Cells through a MicroRNA-339-5p-Dependent Pathway
Author(s) -
Pengcheng Zhang,
Min Zhao,
Shan Huang,
Ping Chen,
Wenyong Wu,
Jin Huang,
Zhengsheng Wu,
Qiang Wu
Publication year - 2016
Publication title -
journal of breast cancer/journal of breast cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 36
eISSN - 2092-9900
pISSN - 1738-6756
DOI - 10.4048/jbc.2016.19.1.26
Subject(s) - skbr3 , cancer research , breast cancer , bcl6 , microrna , cancer , downregulation and upregulation , cell growth , biology , cancer cell , medicine , immunology , b cell , gene , antibody , genetics , germinal center , human breast
Prolactin (PRL) plays a critical role in breast cancer progression by activating its cognate receptor and promotes the growth and differentiation of breast cancer cells. Studies have shown that B-cell lymphoma 6 (BCL6) is the target gene of microRNA-339-5p (miR-339-5p) and that BCL6 expression contributes to breast cancer progression. Herein, we identified PRL as a potent suppressor of BCL6 expression in human breast cancer cells.