Open Access[18F]THK-5351 PET Patterns in Patients With Alzheimer’s Disease and Negative Amyloid PET Findings
Author(s) -
Minyoung Oh,
Jungsu S. Oh,
Seung Jun Oh,
Sang Ju Lee,
Jee Hoon Roh,
Woo Ram Kim,
HaEun Seo,
Jae Myeong Kang,
Sang Won Seo,
J.-H. Lee,
Duk L. Na,
Young Noh,
Jae Seung Kim
Publication year - 2022
Publication title -
journal of clinical neurology/the journal of clinical neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.208
H-Index - 45
eISSN - 2005-5013
pISSN - 1738-6586
DOI - 10.3988/jcn.2022.18.4.437
Subject(s) - pittsburgh compound b , dementia , amyloid (mycology) , positron emission tomography , standardized uptake value , nuclear medicine , medicine , alzheimer's disease , amyloidosis , magnetic resonance imaging , pathology , psychology , disease , radiology
Alzheimer's disease (AD) does not always mean amyloid positivity. [ 18 F]THK-5351 has been shown to be able to detect reactive astrogliosis as well as tau accompanied by neurodegenerative changes. We evaluated the [ 18 F]THK-5351 retention patterns in positron-emission tomography (PET) and the clinical characteristics of patients clinically diagnosed with AD dementia who had negative amyloid PET findings.