Open AccessThe Role of Endothelial Dysfunction in the Pathophysiology and Cerebrovascular Effects of Migraine: A Narrative Review
Author(s) -
Matteo Paolucci,
Claudia Altamura,
Fabrizio Vernieri
Publication year - 2021
Publication title -
journal of clinical neurology/the journal of clinical neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.208
H-Index - 45
eISSN - 2005-5013
pISSN - 1738-6586
DOI - 10.3988/jcn.2021.17.2.164
Subject(s) - pathophysiology , migraine , endothelial dysfunction , narrative review , narrative , medicine , neuroscience , psychology , cardiology , intensive care medicine , literature , art
Migraine is a complex neurovascular disorder whose triggers are not entirely understood. Endothelial dysfunction might play a role in migraine, and there have been numerous reports on endothelium dysfunction and migraine pathophysiology, but their reciprocal cause-effect relationship remains unclear. This review reports the current evidence on endothelium dysfunction, its link with migraine, and its possible consequences for cerebral hemodynamics.