Open AccessShape Analysis of the Subcortical Nuclei in Amyotrophic Lateral Sclerosis without Cognitive Impairment
Author(s) -
Woo Suk Tae,
JungJoon Sung,
Seol-Hee Baek,
Chan-Nyoung Lee,
Byung Jo Kim
Publication year - 2020
Publication title -
journal of clinical neurology/the journal of clinical neurology
Language(s) - English
Resource type - Journals
eISSN - 2005-5013
pISSN - 1738-6586
DOI - 10.3988/jcn.2020.16.4.592
Subject(s) - amyotrophic lateral sclerosis , basal ganglia , neuroscience , psychology , putamen , medicine , anatomy , disease , central nervous system
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that mainly affects the pyramidal motor system. However, recent studies have suggested that degeneration of the extramotor system plays a role in the disability experienced by patients with ALS. We investigated the local shape changes and mean volumes of the subcortical nuclei in sporadic ALS patients with preserved cognition.