Open AccessHigh Cell-Free DNA Levels in Cerebrospinal Fluid Predict Leptomeningeal Seeding of Hematologic Malignancy
Author(s) -
Eun Young Kim,
Sang Kun Lee,
Young Sook Kim,
Ja Min Byun,
Junshik Hong,
Dong Yeop Shin,
Youngil Koh,
Inho Kim
Publication year - 2020
Publication title -
journal of clinical neurology/the journal of clinical neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.208
H-Index - 45
eISSN - 2005-5013
pISSN - 1738-6586
DOI - 10.3988/jcn.2020.16.4.581
Subject(s) - cerebrospinal fluid , malignancy , medicine , cytology , cell free fetal dna , pathology , biomarker , hematologic malignancy , cancer , gastroenterology , biology , pregnancy , fetus , biochemistry , prenatal diagnosis , genetics
The main difficulty when diagnosing leptomeningeal metastases (LMSs) is the low sensitivity of cytology. Cancer cells release cell-free DNA (cfDNA) during proliferation and apoptosis, and so we analyzed the cfDNA level as a biomarker for LMSs in hematologic malignancy.