Open AccessTranscriptome Analysis Identifies Altered Biological Processes and Novel Markers in Human Immunodeficiency Virus-1 Long-Term Non-Progressors
Author(s) -
Dayeon Lee,
Choon Sik Yoon,
Sin Young Choi,
Jung-Eun Kim,
Young-Keol Cho,
ByeongSun Choi,
Jihwan Park
Publication year - 2021
Publication title -
infection and chemotherapy/gam'yeom gwa hwahag yo'beob/infection and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.724
H-Index - 26
eISSN - 2092-6448
pISSN - 1598-8112
DOI - 10.3947/ic.2021.0031
Subject(s) - transcriptome , biology , gene , biological pathway , immune system , viral replication , interferon , gene expression , virus , immunology , computational biology , genetics , virology
The latent reservoir of Human Immunodificiency Virus-1 (HIV-1) has been a major barrier to the complete eradication of HIV-1 and the development of HIV therapy. Long-term non-progressors (LTNPs) are a rare group of patients with HIV-1 who can spontaneously control HIV-1 replication without antiretroviral therapy. Transcriptome analysis is necessary to predict the pathways involved in the natural control of HIV-1, elucidate the mechanisms involved in LTNPs, and find biomarkers for HIV-1 reservoir therapy.