Open AccessThe Impact of Modifying Empirical Antibiotic Therapy Based on Intestinal Colonization Status on Clinical Outcomes of Febrile Neutropenic Patients
Author(s) -
Ali Alrstom,
Tamim Alsuliman,
Nizar Daher,
Raed Abouharb
Publication year - 2021
Publication title -
infection and chemotherapy/gam'yeom gwa hwahag yo'beob/infection and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.724
H-Index - 26
eISSN - 2092-6448
pISSN - 1598-8112
DOI - 10.3947/ic.2020.0111
Subject(s) - medicine , bacteremia , neutropenia , antibiotics , febrile neutropenia , blood culture , colonization , leukopenia , mortality rate , microbiology and biotechnology , chemotherapy , biology
This paper aimed to inspect factors affecting febrile neutropenia patients with hematologic malignancies. The intestinal colonization rate of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) and carbapenem-resistant Enterobacteriaceae (CRE) was assessed. The rate of subsequent ESBL-E and CRE bacteremia correlated with corresponding bacterial colonization was evaluated. Further, the risk factors for ESBL-E and CRE intestinal colonization were examined. Finally, the impact of rectal swab screening combined with adapted empirical antibiotic therapy on the mortality rate of patients with febrile neutropenia was assessed.