Open AccessExtravasated platelet aggregation contributes to tumor progression via the accumulation of myeloid‑derived suppressor cells in gastric cancer with peritoneal metastasis
Author(s) -
Takahisa Yamaguchi,
Sachio Fushida,
Jun Koyama,
Mitsuyoshi Okazaki,
Satoko Ishikawa,
Yoshinao Ohbatake,
Shiro Terai,
Koichi Okamoto,
Shinichi Nakanuma,
Isamu Makino,
Keisuke Nakamura,
Tomoharu Miyashita,
Hidehiro Tajima,
Hiroyuki Takamura,
Itasu Ninomiya,
Tetsuo Ohta
Publication year - 2020
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2020.11722
Subject(s) - medicine , metastasis , cancer , cancer research , foxp3 , cancer cell , tumor microenvironment , myeloid derived suppressor cell , tumor progression , immunology , pathology , immune system , suppressor
Extravasated platelet aggregation (EPA) serves an important role in the cancer microenvironment during cancer progression, and has been demonstrated to interact with tumor cells in several types of cancer. EPA induces epithelial-mesenchymal transition (EMT) via transforming growth factor-β, and also recruits immunosuppressive cells, including regulatory T (Treg) cells and myeloid-derived suppressor cells (MDSCs). However, the role of EPA in gastric cancer with peritoneal metastasis remains unknown. The present study analyzed the association between EPA and prognosis in patients with gastric cancer with peritoneal metastasis. The present study evaluated 62 patients diagnosed with advanced gastric cancer with peritoneal metastasis between 2001 and 2016. EPA, EMT, Treg cells and MDSCs in peritoneal metastatic lesions were detected by immunohistochemical evaluation of CD42b, SNAIL, FOXP3 and CD33, respectively. CD42b expression was observed in 56.5% (35/62) of peritoneal metastatic lesions. CD42b expression in peritoneal metastatic lesions was associated with poor overall survival compared with lower frequencies (hazard ratio, 2.03; 95% confidence interval, 1.12-3.69; P=0.018). SNAIL, FOXP3 and CD33 expression were not associated with overall survival, but CD33 expression was markedly higher in CD42b-positive patients (P=0.022). These results indicated that EPA affects immunosuppression by recruiting MDSCs in the tumor microenvironment via the secretion of soluble factors, resulting in tumor progression. EPA may be a novel therapeutic target for gastric cancer with peritoneal metastasis.