Open AccessTumor suppressor role of miR‑876‑5p in gastric cancer
Author(s) -
Hongwei Zhao,
Yuzhu Zheng,
Jun You,
Jingyuan Xiong,
Ying Shi,
Linshen Xie,
XianRong Song,
Yuqin Yao,
Zhao-Hui Jin,
Chaoxiong Zhang
Publication year - 2020
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2020.11680
Subject(s) - oncogene , cancer , microrna , cancer research , cell cycle , gene knockdown , molecular medicine , apoptosis , cell growth , lung cancer , suppressor , biology , cisplatin , oncology , medicine , gene , biochemistry , chemotherapy
Gastric cancer (GC) is the second most common cancer cause of cancer-related mortality worldwide. Recent studies have demonstrated the function of microRNAs (miRNAs) in the pathogenesis of GC. miR-876-5p demonstrated an antitumor role in hepatocellular carcinoma and lung cancer; however, the function of miR-876-5p has not yet been fully identified in GC. Thus, the present study aimed to investigate the role of miR-876-5p in GC. The results of the present study demonstrated low expression levels of miR-876-5p in GC tumor tissues. Furthermore, overexpression of miR-876-5p inhibited GC cell proliferation and promoted apoptosis, whilst miR-876-5p knockdown promoted GC cell proliferation and decreased cisplatin sensitivity of GC cells. Transforming growth factor β-receptor 1 was demonstrated to be a potential target gene of miR-876-5p. Overall, the results of the present study suggest that miR-876-5p plays an antitumor role in GC.