Open AccessSPINK1 is a prognosis predicting factor of non‑small cell lung cancer and regulates redox homeostasis
Author(s) -
Maoqing Guo,
Xuan Zhou,
Xiao Han,
Youwen Zhang,
Luning Jiang
Publication year - 2019
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2019.11005
Subject(s) - cancer , oncogene , homeostasis , biology , lung cancer , cancer research , cell growth , apoptosis , cell , oxidative stress , cell cycle , medicine , microbiology and biotechnology , endocrinology , biochemistry
Serine protease inhibitor Kazal-type 1 (SPINK1) is a trypsin kinase inhibitor, which is involved in the development of inflammation, cell proliferation and cancer development and progression. However, the prognostic value of SPINK1 in non-small cell lung cancer (NSCLC) and its ability to regulate intrinsic redox homeostasis have, to the best of our knowledge, not been previously investigated. In the present study, it was revealed that SPINK1 is highly expressed in NSCLC tissue samples compared with normal tissue samples, and may be a potential prognostic marker of NSCLC. Functional analyses demonstrated that SPINK1 promoted tumor cell growth and inhibited apoptosis through maintaining redox homeostasis by regulating the nuclear factor erythroid 2-related factor 2 pathways. It has been proposed that SPINK1 could be a prognostic marker of NSCLC and a novel antioxidant promoter under oxidative stress conditions in NSCLC.