Open AccessRole of different immune cells and metabolic pathways in modulating the immune response in pancreatic cancer (Review)
Author(s) -
Nnenna Elebo,
Pascaline Fru,
Jones OmoshoroJones,
Geoffrey Candy,
Ekene Emmanuel Nweke
Publication year - 2020
Publication title -
molecular medicine reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.727
H-Index - 56
eISSN - 1791-3004
pISSN - 1791-2997
DOI - 10.3892/mmr.2020.11622
Subject(s) - pancreatic cancer , immune system , cancer , carcinogenesis , oncogene , cancer research , cancer cell , biology , molecular medicine , cell cycle , metabolic pathway , immunology , endocrinology , metabolism , genetics
Pancreatic cancer is an aggressive cancer, making it a leading cause of cancer‑related deaths. It is characteristically resistant to treatment, which results in low survival rates. In pancreatic cancer, immune cells undergo transitions that can inhibit or promote their functions, enabling treatment resistance and tumor progression. These transitions can be fostered by metabolic pathways that are dysregulated during tumorigenesis. The present review aimed to summarize the different immune cells and their roles in pancreatic cancer. The review also highlighted the individual metabolic pathways in pancreatic cancer and how they enable transitions in immune cells. Finally, the potential of targeting metabolic pathways for effective therapeutic strategies was considered.