Open AccessCathepsin S as a target in gastric cancer (Review)
Author(s) -
Adriano Carneiro da Costa,
Fernando SantaCruz,
Luiz Alberto Reis Mattos,
Maria Améllia R Aquino,
Camila Ramos Martins,
Álvaro Antônio Bandeira Ferraz,
José Luiz Figueiredo
Publication year - 2019
Publication title -
molecular and clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.442
H-Index - 7
eISSN - 2049-9469
pISSN - 2049-9450
DOI - 10.3892/mco.2019.1958
Subject(s) - cancer , oncogene , metastasis , cancer research , molecular medicine , cathepsin , biology , medicine , bioinformatics , cell cycle , oncology , pathology , enzyme , biochemistry
Cathepsin S (Cat S) is a protein expressed in some epithelial cells, which appears to be associated with cancer metastasis and recurrence. The abnormal expression of Cat S has been reported to be associated with the progression of certain types of gastrointestinal neoplasms, including gastric cancer (GC). There is a need to identify novel biomarkers and therapeutic targets associated with the growth, invasion and migration of GC cells, in order to develop non-invasive diagnostic and prognostic procedures and design new therapeutic approaches. The aim of the present study was to assess the association between Cat S and oncogenic processes implicated in the development of GC, focusing on the diagnostic and therapeutic potential of this molecule in GC. A search was conducted through the PubMed and Cochrane Central Register of Controlled Trials electronic databases for relevant literature published between 2003 and 2018, using the mesh terms 'cathepsin S' and 'cancer' and 'gastric cancer'.