Open AccessDYRK1A suppression attenuates HIF‑1α accumulation and enhances the anti‑liver cancer effects of regorafenib and sorafenib under hypoxic conditions
Author(s) -
Chong Zhang,
Liquan Wu,
Zhi-di Li,
Manman Zhang,
Jie Wu,
Feihua Du,
LingHui Zeng,
Yang-ling Li
Publication year - 2022
Publication title -
international journal of oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.405
H-Index - 122
ISSN - 1019-6439
DOI - 10.3892/ijo.2022.5335
Subject(s) - sorafenib , regorafenib , biology , cancer research , harmine , cancer cell , liver cancer , gene knockdown , protein kinase b , transfection , mapk/erk pathway , kinase , signal transduction , pharmacology , apoptosis , cancer , cell culture , microbiology and biotechnology , biochemistry , hepatocellular carcinoma , colorectal cancer , genetics