Open AccessTriamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series
Author(s) -
Marius Cristian Suta,
Olimpiu Karancsi,
Ovidiu Muşat,
Nicolae Constantin Balica,
Iasmina Yasar,
Elena Cecilia Roşca,
Simona Stanca,
DianaMaria Dărăbuş
Publication year - 2020
Publication title -
experimental and therapeutic medicine
Language(s) - English
Resource type - Journals
eISSN - 1792-1015
pISSN - 1792-0981
DOI - 10.3892/etm.2020.8883
Subject(s) - endophthalmitis , triamcinolone acetonide , uveitis , ophthalmology , medicine , dermatology , molecular medicine , acetonide , cell cycle , cancer
Due to their anti-inflammatory, antiangiogenic and antiedematous properties, corticosteroids have been commonly used in the treatment of retinal diseases. Intravitreal administration of steroids offers the maximal drug efficacy and the lowest risk of systemic side effects. The authors report three cases of presumed sterile endophthalmitis induced by triamcinolone acetonide (TA) in three eyes with intermediate non-infectious uveitis. Each patient received a single intravitreal injection of TA of 4 mg. Because of the intense vitreous inflammatory reaction, retina examination and the optical coherence tomography could not be performed, although vitreous opacities were observed on the ocular ultrasound. The dense vitreous opacity is a defining factor, the anterior segment inflammation is mild to moderate and a hypopyon is present, which may be a sterile inflammatory reaction or the triamcinolone material itself. In cases of sterile endophthalmitis, the visual acuity increases progressively as the intraocular inflammation diminishes. Local treatment with topical antibiotics, prednisolone acetate and cycloplegic eyedrops is recommended to control the inflammatory reaction.