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We present Hubble Space Telescope WFC3/UVIS (F275W, F336W) and ACS/WFCoptical (F435W, F555W, and F814W) observations of the nearby grand-designspiral galaxy M101 as part of the Legacy Extragalactic UV Survey (LEGUS).Compact sources detected in at least four bands were classified by both humanexperts and the convolutional neural network StarcNet. Human experts classifiedthe 2,351 brightest sources, retrieving $N_{c} = 965$ star clusters. StarcNet,trained on LEGUS data not including M101, classified all 4,725 sources detectedin four bands, retrieving $N_{c} = 2,270$ star clusters. The combined catalogrepresents the most complete census to date of compact star clusters in M101.We find that for the 2,351 sources with both a visual- and ML-classificationStarcNet is able to reproduce the human classifications at high levels ofaccuracy ($\sim 80-90\%$), which is equivalent to the level of agreementbetween human classifiers in LEGUS. The derived cluster age distributionimplies a disruption rate of $dN/d\tau \propto \tau^{-0.45 \pm 0.14}$ over$10^{7} < \tau < 10^{8.5}$yr for cluster masses $\geq 10^{3.55} M_{\odot}$ forthe central region of M101 and $dN/d\tau \propto \tau^{-0.02 \pm 0.15}$ forcluster masses $\geq 10^{3.38} M_{\odot}$ in the northwest region of thegalaxy. The trends we recover are weaker than those of other nearby spirals(e.g. M51) and starbursts, consistent with the M101 environment having alower-density interstellar medium, and providing evidence in favor ofenvironmentally-dependent cluster disruption in the central, southeast, andnorthwest regions of M101.

Star Cluster Formation and Evolution in M101: An Investigation with the Legacy Extragalactic UV Survey