Open AccessOxidized low-density lipoprotein stimulates CD206 positive macrophages upregulating CD44 and CD133 expression in colorectal cancer with high-fat diet
Author(s) -
Shangen Zheng,
Hao Chen,
Weihong Sha,
Xiaofen Chen,
Jian-Bin Yin,
Xiaobo Zhu,
Zhong-Wen Zheng,
Juan Ma
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i34.4993
Subject(s) - hyperlipidemia , colorectal cancer , cd44 , scavenger receptor , medicine , downregulation and upregulation , chemistry , lipoprotein , ldl receptor , receptor , endocrinology , macrophage , cancer research , cell , cancer , cholesterol , biochemistry , in vitro , diabetes mellitus , gene
Oxidized low-density lipoprotein (ox-LDL), which is abnormally increased in the serum of colorectal cancer (CRC) patients consuming a high-fat diet (HFD), may be one of the risk factors for the development of CRC. Ox-LDL exerts a regulatory effect on macrophages and may influence CRC through the tumor microenvironment. The role of ox-LDL in CRC remains unclear.