Open AccessInvolvement of toll-like receptor 5 on mouse model of colonic hypersensitivity induced by neonatal maternal separation
Author(s) -
Geoffroy Mallaret,
Amandine Lashermes,
Mathieu Méleine,
Ludivine Boudieu,
J. Barbier,
Youssef Aissouni,
Agathe Gelot,
Benoît Chassaing,
Andrew T. Gewirtz,
Denis Ardid,
Frédéric A. Carvalho
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i29.3903
Subject(s) - dysbiosis , intestinal permeability , irritable bowel syndrome , immunology , gut flora , tlr5 , innate immune system , tlr2 , toll like receptor , medicine , biology , endocrinology , immune system
Chronic abdominal pain is the most common cause for gastroenterology consultation and is frequently associated with functional gastrointestinal disorders including irritable bowel syndrome and inflammatory bowel disease. These disorders present similar brain/gut/microbiota trialogue alterations, associated with abnormal intestinal permeability, intestinal dysbiosis and colonic hypersensitivity (CHS). Intestinal dysbiosis can alter colon homeostasis leading to abnormal activation of the innate immunity that promotes CHS, perhaps involving the toll-like receptors (TLRs), which play a central role in innate immunity.