Open AccessMachine perfusion of the liver: Putting the puzzle pieces together
Author(s) -
Yuri L. Boteon,
Paulo N. Martins,
Paolo Muiesan,
Andrea Schlegel
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i34.5727
Subject(s) - machine perfusion , perfusion , liver transplantation , realm , medicine , transplantation , computer science , united network for organ sharing , process (computing) , reperfusion injury , ischemia , intensive care medicine , surgery , radiology , political science , law , operating system
The realm of extended criteria liver transplantation created the 'adjacent possible' for dynamic organ preservation. Machine perfusion of the liver greatly expanded donor organ preservation possibilities, reaching before unattainable goals, including the mitigation of ischemia-reperfusion injury, viability assessment, and organ reconditioning prior to transplantation. However, current scientific evidence lacks uniformity between studies, perfusion protocols, and acceptance criteria. Construction of collaborative research networks for sharing knowledge should, therefore, enable the development of high-level evidence and guidelines for machine perfusion utilization, including donor acceptance criteria. Finally, this approach shall guarantee conditions for further progress to occur.